Mycobiology  2001;29(3):170-172

Cytotoxicity of Paecilomyces tenuipes Against Human Carcinoma Cells, HepG2 and MCF-7 In Vitro.

Joong Sup SHIM 1 ; Hae Ryong CHANG ; Eung Gi MIN ; Yong Hae KIM ; Yeong Hwan HAN

Affiliations

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Keywords

Cytotoxicity; Fruiting body; Paecilomyces tenuipes

Country

Republic of Korea

Language

English

Abstract

The methanolic extract of fruiting body of Paecilomyces tenuipes DGUM 32001 showed significant cytotoxicity against human cancer cells: HepG2 and MCF-7. The methanolic extract was further fractionated with organic solvents such as chloroform and ethyl acetate in that order. Among the fractions tested, the ethyl acetate fraction showed the highest cytotoxicity against the carcinoma tested. The IC50 values of ethyl acetate fraction against HepG and MCF-7 were 40 and 9.6 microg/ml, respectively.