Pediatric Gastroenterology, Hepatology & Nutrition  2015;18(2):144-148

doi:10.5223/pghn.2015.18.2.144

Atypical beta-Catenin Activated Child Hepatocellular Tumor.

Aynur TURAN 1 ; Havva Akmaz UNLU ; Esra KARAKUS ; Arzu YAZAL ERDEM ; Zeynep Ilerisoy YAKUT

Affiliations

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Keywords

Adenoma; Liver; Hepatocellular carcinoma; Magnetic resonance imaging; Beta-catenin

Country

Republic of Korea

Language

English

Abstract

Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features. The beta-catenin activated subtype accounts for 10-15% of all hepatocellular adenomas and specific magnetic resonance imaging features have been defined for different hepatocellular adenomas subtypes. The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of beta-catenin activated hepatocellular adenomas in a child. In this case, atypical diffuse steatosis was determined in the lesion. In the literature, diffuse steatosis, which is defined as a feature of the hepatocyte nuclear factor-1alpha-inactivated hepatocellular adenomas subtype, has not been previously reported in any beta-catenin activated hepatocellular adenomas case. Interlacing magnetic resonance imaging findings between subtypes show that there are still many mysteries about this topic and larger studies are warranted.