Journal of Korean Medical Science  2002;17(5):704-707

doi:10.3346/jkms.2002.17.5.704

Plasma Cell Granuloma in Cyclosporine-Induced Gingival Overgrowth: A Report of Two Cases with Immunohistochemical Positivity of Interleukin-6 and Phospholipase C-gamma1.

Sung Sook KIM 1 ; Dae Woon EOM ; Joo Ryung HUH ; Iel Yong SUNG ; In Pyo CHOI ; Sung Ho RYU ; Pann Ghill SUH ; Sung Min CHUNG

Affiliations

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Keywords

Cycosporin; Side Effect; Gingival Overgrowth; Plasma Cells; Interleukin-6; Phospholipase C

Country

Republic of Korea

Language

English

Abstract

We report two cases of gingival plasma cell granuloma in a 34-yr-old and 40-yr-old two male renal transplant recipients with cyclosporine A (CsA)-induced gingival overgrowth (GO). Histologically, these lesions were composed of mature plasma cells, showing polyclonality for both lambda and kappa light chains and fibrovascular connective tissue stroma. In addition to the fact that CsA-induced plasma cell granuloma is rare, the salient features of our cases were the secretion of interleukin-6 and overexpression of phospholipase C-gamma1 of the tumor cells, which may explain the mechanisms of CsA- induced GO.