Journal of the Korean Academy of Rehabilitation Medicine  2008;32(4):469-471

Teicoplanin-induced Elevation of Plasma Creatine Phosphokinase in the Patient with Wound Infection: A case report.

Geun Young PARK 1 ; Joo Hyun PARK ; Yun Hee KIM ; Sae Hyun KIM ; Byung Woo YANG

Affiliations

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Keywords

Teicoplanin; Creatine phosphokinase (CPK); Pressure sore

Country

Republic of Korea

Language

Korean

Abstract

The use of teicoplanin is increasing with increase in the incidence of wound infections caused by methicillin-resistant Staphylococcus aureus. Teicoplanin has longer half-life than vancomycin, so it can be administerd once daily, whereas vancomycin has to be administered 3~4 times daily. Teicoplanin is known to have lesser side effect profiles than vancomycin, such as skin eruptions, ototoxicity and nephrotoxicity. A 27-year old women in vegetative state had a grade 3 pressure sore at coccyx area. We prescribe teicoplanin to manage wound infected by methicillin-resistant Staphylococcus aureus. Plasma creatine phosphokinase (CPK) was elevated abruptly at 9th day of teicoplanin therapy. Five days after discontinuation of teicoplanin, CPK was normalized. We experienced a case of elevation of plasma creatine phosphokinase associated with teicoplanin.