Korean Journal of Hematology  2002;37(2):143-146

Nonmyeloablative Stem Cell Transplantation in a Patient with Refractory Acute Myeolgeous Leukemia with Central Diabetes Insipidus.

Young Shin KIM 1 ; Inho KIM ; Hyun Min PARK ; Moon Hee LEE ; Chul Soo KIM

Affiliations

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Keywords

Diabetes insipidus (DI); Acute myelogous leukemia (AML); Non-myeloablative stem cell transplantation (NST)

Country

Republic of Korea

Language

Korean

MeSH

Abstract

A 31-year-old man presented fatigue, polydipsia and polyuria. He was diagnosed as acute myelogenous leukemia (AML) FAB-M1, and a water deprivation test confirmed central diabetes insipidus (DI). A sella magnetic resonance imaging showed the thickening of pituitary stalk with contrast enhancement suggesting leukemic infiltration. He was treated with remission induction chemotherapy including cytosine arabinoside and idarubicin, and concurrent intrathecal methotrexate, cytosine arabinoside and hydrocortisone. But he was not achieved a remission. Reinduction chemotherapy was also failed to induce remission. He underwent a non-myeloablative allogeneic he matopoietic stem cell transplantation (NST) from HLA one antigen mismatched sibling donor for refractory AML. After transplantation, he had no evidence of leukemia and DI, He showed complete conversion of donor chimerism. By day 7 after NST, desmopressin (DDAVP) was no longer required and a follow-up at 9 months he has no evidence of relapse. We report a rare case recovered from diabetes insipidus associated with acute myelogenous leukemia after NST in Korea.