Korean Journal of Hematology  2009;44(3):163-167

doi:10.5045/kjh.2009.44.3.163

Post-operative Bleeding due to Acquired Hemophilia Successfully Treated with Recombinant Factor VIIa: Case Report.

Naria LEE 1 ; Seong Hoon YOON ; Won LIM ; Mi Hyun KIM ; Hyo Jeong KIM ; Seon Kyeong KIM ; Jin Sup PARK ; Young Mi SEOL ; Moo Kon SONG ; Young Jin CHOI ; Joo Seop CHUNG ; Goon Jae CHO

Affiliations

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Keywords

Acquired hemophilia; Recombinant activated factor VII; Acute bleeding

Country

Republic of Korea

Language

Korean

Abstract

Acquired hemophilia is a rare but potentially life-threatening hemorrhagic disorder caused by the development of autoantibodies against coagulation factor VIII. Concentrates of human factor VIII, desmopressin, activated prothrombin complex concentrates, recombinant activated factor VII can all be used to control episodes of acute bleeding. The recent availability of bypassing agents like recombinant activated factor VII has been shown to be clinically safe and effective as treatment for acute bleeding. In this case report, a 67 year-old male patient with Rh negative blood type developed gross hematuria and bleeding after transurethral resection due to prostatic hypertrophy. After vesicocutaneous fistular reduction operation, post-operative bleeding was presented. The acute bleeding was controlled successfully by the combined treatment with recombinant activated factor VII (Novo seven(R)) and prednisone.