Korean Journal of Hematology  2009;44(3):172-176

doi:10.5045/kjh.2009.44.3.172

A Case of Multicentric Castleman's Disease Diagnosed with Lymph Node Biopsy and Bone Marrow Examination.

Sang Hyuk PARK 1 ; Chan Jeoung PARK ; Jooryung HUH ; Seongsoo JANG ; Hyun Sook CHI ; Cheolwon SUH

Affiliations

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Keywords

Multicentric Castleman's disease; Lymph node biopsy; Bone marrow examination

Country

Republic of Korea

Language

Korean

Abstract

Castleman's disease (CD) is an uncommon lymphoproliferative disorder presenting with a variable spectrum of clinical manifestations. CD is classified into two subtypes, Localized CD and Multicentric CD, by clinical manifestation, and is divided into 2 histopathologic types: a hyaline-vascular type (HV) or a plasma-cell type (PC). Multicentric CD show PC type predominantly and show systemic symptoms, such as fever, night sweat, malaise, ascites, edema, and more than half show multiple lymphadenopathy and hepatosplenomegaly. We report a case of 67 year old man with multicentric CD presented with fever of unknown origin and diagnosed with lymph node biopsy and bone marrow examination with a brief review of the literature.