Clinical Pediatric Hematology-Oncology  2018;25(2):170-174

doi:10.15264/cpho.2018.25.2.170

Cytomegalovirus-Associated Severe Direct Antiglobulin Test Negative Hemolytic Anemia: A Case Report.

Hyun Jung HONG 1 ; Young Hye CHO ; Jae Young LIM ; Jung Sook YEOM ; Ji Sook PARK ; Eun Sil PARK ; Ji Hyun SEO ; Hyang Ok WOO ; Hee Shang YOUN

Affiliations

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Keywords

Hemolytic anemia; Cytomegalovirus

Country

Republic of Korea

Language

English

Abstract

Cytomegalovirus is a common virus that is mostly asymptomatic when infected, but rarely causes life-threatening hemolysis especially in immunocompromised children. We report a case of antiglobulin test negative severe hemolytic anemia caused by cytomegalovirus infection developed in an immune competent 9-year-old girl. The patient's hemoglobin level was 4.8 g/dL on the day of admission. The diagnosis was achieved by exclusion of other causes of hemolytic anemia and serological evidence of recent CMV infection. The patient was successfully treated with anti-viral agents and steroids resulting in recovery from anemia. Clinicians should consider cytomegalovirus infection in the differential diagnosis of hemolytic anemia in pediatric patients.