PURPOSE: This study was to investigate the performance of safety care activities among nurses in small-medium sized general hospitals and to identify factors associated with the safety care activities. METHODS: In this cross-sectional descriptive study, 455 nurses were recruited from small-medium sized general hospitals. Data were collected with the ‘Questionnaire on Patient Safety Care Activities’ by web based survey. Descriptive statistics, independent t-test and One-way ANOVA with Duncan test for multiple comparison were used for data analysis. RESULTS: The mean score of patient safety care activity was 4.52 out of a total of 5 points. The total score of patient safety care activities according to the characteristics of the subjects was significantly higher than those of patients who had more than 15 years of clinical nursing career (F=7.06, p < .001) and there was a significant difference according to experience of healthcare accreditation (t=−2.10, p=.036). CONCLUSION: In order to raise the level of patient safety care activity among nurses in small-medium sized general hospitals, it is important to retain experienced nurses. Practical training and regular educations on patient safety care activities are required for nurses in small-medium sized general hospitals.