Psychiatry Investigation  2017;14(1):107-109

doi:10.4306/pi.2017.14.1.107

Reconsidering Clinical Staging Model: A Case of Genetic High Risk for Schizophrenia.

Tae Young LEE 1 ; Minah KIM ; Sung Nyun KIM ; Jun Soo KWON

Affiliations

+expand

Keywords

Clinical staging model; Schizophrenia; Clinical high risk; Genetic vulnerability

Country

Republic of Korea

Language

English

Abstract

The clinical staging model is considered a useful and practical method not only in dealing with the early stage of psychosis overcoming the debate about diagnostic boundaries but also in emerging mood disorder. However, its one limitation is that it cannot discriminate the heterogeneity of individuals at clinical high risk for psychosis, but lumps them all together. Even a healthy offspring of schizophrenia can eventually show clinical symptoms and progress to schizophrenia under the influence of genetic vulnerability and environmental stress even after the peak age of onset of schizophrenia. Therefore, individuals with genetic liability of schizophrenia may require a more intensive intervention than recommended by the staging model based on current clinical status.