Objective To investigate the safety and efficacy of selective laser trabeculoplasty(SLT)in primary open-angle glaucoma(POAG).Design Retrospective case series.Participants 47 cases(62 eyes)of POAG patients.Methods 62 eyes of 47 patients with primary open-angle glaucoma were treated with frequency doubled Nd:YAG laser SLT(Selecta Duet).A total of approximately 50 non-overlapping spots were placed over 180 degrees of the trabecular meshwork with energy levels ranging from 0.5 to 1.4 mJ per pulse.After surgery,patients were maintained with the drug regimen identical to that before treatment.The average follow-up was 12 months.Main Outcome Measures Intraocular pressure(IOP)and complications.Results After 1 year,the average reduction in IOP from the baseline was 5.2 mmHg.The IOP of 72.5% eyes were controlled well.Slight inflammation of anterior chamber occurred in all the cases 1 hour later after SLT and disappered 3 days later automatically.Conclusions SLT is an effective and safe method to lower IOP in primary open-angle glaucoma in the one year follow up.