Chinese Journal of Clinical Pharmacology and Therapeutics 1999;0(04):-

Clinical use of mycophenolate mofetil in renal taransplation

Ya-Lin DONG ; Mao-Yi WANG ; Meng HUANG ; Pu-Xun TIAN ; Sheng-Qiang PANG ;

Keywords

mycophenolate mofetil; cyclosporine A:renal transplants; clinic

Country

China

Language

Chinese

Abstract

Aim To monitor the whole blood trough concentration of cyclosporine A (CsA) in renaltransplant recipients reciving triple therapy with mycophenolate mofetil, cyclosporine andprednisone and to establish an optimal therapeutic window of CsA. Methods Sampleswere measured by specific fluorescence polarization immunoassay. According to the timeafter operation and different therapy plan, the whole blood trough concentration of CsA ineach group was compared with that in control group.Results The optimal therapeuticwindow of CsA with MMF plan was 150~300 ?g? L-1 (less than one month after op-eration), 120~260?g?L-1 (1~