Chinese Journal of Clinical Pharmacology and Therapeutics 1999;0(04):-

Study of the antiulcer effect of pantoprazole

Ying-Xin WANG ; Xiao-Qiang LI ; Guang-Wu WU ; Shan-Jun QIAN ; Hong LEI ; Chang CAO ;

Keywords

pantoprazole sodium; experimental ulcer; gastric acid

Country

China

Language

Chinese

Abstract

Aim To evaluate the effects of pantoprazole on various experimental acute ulcer inrats and mice. Methods The model of a gastric ulcer of rats or mice was caused bystree- induced ulcer and ligatel pylurus-induced ulcer. Results & Conclusions At adose of 5, 10, 20 mg? kg-1 of Pantoprazole can markedly decrease the ulcer index ofstree-induced ulcer. Pantoprazole(4, 8, 16 mg? kg -1 ) significantly decrease the areaof ligated pylorus-induced gastric ulcer. It was also found that pantoprazole caninhibit the output of basic gastric acid.