Objective To explore the relationship between Body Mass Index (BMI), Waist-Hips-Ratio (WHR) and Blood lipids.Methods Body measurements including BMI, WHR and body fat percentage (FAT%), and blood lipid profile assessment and liver ultrasonography were conducted on 350 employees from Shanghai Waigaoqiao Free Trade Zone from January 2006 to August 2007. All subjects were classified into a group of overweight/obesity and a group of normal body weight based on their BMI. BMI, WHR, FAT%, blood lipid profile, the prevalence of fatty liver and dyslipidemia were compared between the two groups. Results WHR, FAT%, the level of TG and TC in overweight/obesity group were significantly higher than that in normal body weight group(P=0.000), but the level of HDL-C was significantly lower than that in normal body weight group (P=0.000). The prevalence of central obesity (88.70%), fatty liver (72.32%), and hypertriglyceridemia (49.7%),hypercholesterolemia (33.89%), low HDL-C (40.68%) in overweight/obesity group were significantly higher than those in normal body weight group (P=0.000). Concludes BMI, WHR were associated with blood lipids. Early identification and intervention on these people with high risk of cardiovascular diseases are possible by body measurement, which are significant for predicting and reducing the occurrence of cardiovascular diseases.