Fudan University Journal of Medical Sciences 2017;44(6):773-785

doi:10.3969/j.issn.1672-8467.2017.06.0014

Defeating enemy outside the border-development of viral entry inhibitors

bo Shi JIANG 1 ; Shan SU ; Shuai XIA ; Peng ZOU ; Lu LU

Affiliations

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Keywords

highly pathogenic viruses; virus entry inhibitors; virus inactivators

Country

China

Language

Chinese

Abstract

About 25 years ago,we had pioneered the research fields of developing human immunodeficiency virus (HIV) fusion/entry inhibitors and anti-HIV peptide drugs.Over the past six years,we have gained some promising results in research and development of the HIV,Middle East respiratory syndrome coronavirus (MERS-COV),the Ebola virus (EBOV),and the Zika virus (ZIKV) entry inhibitors.This article provides an overview of the research progress of viral entry inhibitors against the related highly pathogenic viruses.