Congenital heart disease (CHD) is the most common congenital malformations.It occurs under the combined effect of genetic and environmental factors.In recent years,the correlation of key nutritional factors,the modifiable environmental factors,with the occurrence risk of CHD has attracted increasing attention.One of the most representative key nutritional factors is folic acid,and many studies suggest that maternal folic acid supplementation during periconceptional period could reduce the risk of CHD occurrence.However,many challenges remain in order to clarify the relationship between folic acid and CHD,which is worthy of further study.