Journal of Genetic Medicine  2012;9(1):22-24

doi:10.5734/JGM.2012.9.1.22

Fetal Loss Rate after Mid-trimester Amniocentesis.

You Jung HAN 1 ; Yun Young KIM ; Si Won LEE ; Min Hyoung KIM ; Jin Hoon CHUNG ; Hyun Kyong AHN ; Jung Yeol HAN ; Moon Young KIM ; Jae Hyug YANG ; Kyu Hong CHOI ; So Yeon PARK ; Hyun Mee RYU

Affiliations

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Keywords

Amniocentesis; Fetal loss rate

Country

Republic of Korea

Language

English

Abstract

PURPOSE: The aim of this study was to asses the fetal loss rate after mid-trimester amniocentesis. MATERIALS AND METHODS: This was a retrospective cohort study including singleton pregnant women who underwent mid-trimester amniocentesis at Cheil General Hospital from January 2008 through December 2010. The procedure-related fetal loss was defined as miscarriage within 2 weeks after amniocentesis. We evaluated the fetal loss rate within 2 weeks after amniocentesis and fetal loss rate before 24 gestational weeks. RESULTS: During the study period, a total of 4,356 singleton pregnant women underwent mid-trimester amniocentesis. A total of Five hundred ninety six women were excluded owing to follow up loss and termination of pregnancy due to abnormal karyotype or major anomaly. At our institute, the fetal loss rate within 2 weeks was 0.1% and before 24 gestational weeks was 0.3% after amniocentesis. CONCLUSION: The fetal loss rate after mid-trimester amniocentesis in our study is lower than previously reported rate. We suggest that amniocentesis is a safe procedure.