Chinese Journal of Urology 2017;38(z1):57-60

doi:10.3760/j.issn.1000-6702.2017.z1.016

Expression and significance of CD68 and TGF-β2 in benign prostatic hyperplasia

Haidong CAO 1 ; Dongwen WANG ; Xiaoming CAO ; Wei ZHANG ; Xin WANG ; Changjian ZHAO

Affiliations

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Keywords

Benign prostatic hyperplasia; CD68; Transforming growth factor-β2

Country

China

Language

Chinese

Abstract

Objective To study the expression and significance of CD68 and TGF-β2 in benign prostatic hyperplasia(BPH).Methods The immunohistochemistry PV two step method was used to detect the expression level of CD68 and TGF-β2 in 90 cases of benign prostatic hyperplasia and combined with clinical data were analyzed.Results Positive rate of CD68 as macrophages marker was 86%(77/90) in the epithelial cells,positive rate of TGF-β2 as transforming growth factor marker was 79%(71/90) in epithelial cells and stromal cells. Immune inlfammation mediated by macrophages,with coloring degree deepening,the degree of immune inlfammation increased,larger prostate volume(P<0.01),IPSS score higher (P<0.01),maximum urinary lfow rate lower(P<0.01),the dffierences between groups were statistically significant.Conclusions This point may indicate immune inlfammation play an important role in the development process of BPH and help to complete the pathogenisis theory.