Chinese Journal of Internal Medicine 2018;57(1):54-56

doi:10.3760/cma.j.issn.0578-1426.2018.01.010

Outcomes of alternative donor allogeneic hematopoietic stem cell transplantation for Fanconi anemia:a five cases report

Wenjing WANG 1 ; Yuqian SUN ; Feifei TANG ; Tingting HAN ; Xiaodong MO ; Jingzhi WANG ; Xiaohui ZHANG ; Xiaojun HUANG ; Lanping XU

Affiliations

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Keywords

Fanconi anemia; Hematopoietic stem cell transplantation; Haploidentical; Matched unrelated donor

Country

China

Language

Chinese

Abstract

Five patients with Fanconi anemia who received hematopoietic cell transplantation were retrospectively analyzed. The conditioning regimens included fludarabine, cyclophosphamide and anti-thymocyte globulin. Two patients received both bone marrow and peripheral blood stem cells as the source of stem cell grafts from haploidentical matched related donors, while the others received peripheral blood stem cells from unrelated donors.All patients tolerated well and reached hematopoietic reconstitution. One patient died of intracranial infection.During follow-up,4 patients survived independent of transfusion with full donor chimerism.