Objective To analysis of the relationship between Lp-PLA2 and type 2 diabetes,and to further explore the Lp-PLA2 in complications of type 2 diabetes in the occurrence and development of the role and clinical significance through the detection of serum in patients with type 2 diabetes mellitus lipoprotein associated phospholipase A2(Lp-PLA2)level.Meth-od 189 patients with type 2 diabetes in the department of endocrinology of shaanxi people's hospital were selected and di-vided into 3 groups,including 49 patients with type 2 diabetes mellitus,type 2 diabetes mellitus with hyperlipidemia patients 56 cases,type 2 diabetes mellitus with atherosclerosis 84 cases.At the same time,65 cases of normal control group were se-lected.The levels of Lp-PLA2 and HbA1c were detected,and the results were compared among the groups.Results The levels of Lp-PLA2 in type 2 diabetes mellitus group(184.83±23.33 ng/ml),type 2 diabetes mellitus complicated with hy-perlipidemia group(204.06 ± 28.05 ng/ml),type 2 diabetes mellitus complicated with atherosclerosis group(231.50 ± 38.19 ng/ml)were higher than those in control group(88.51±21.91 ng/ml),and the difference between the four groups was statistically significant(F=194.78,P<0.01).In the simple type 2 diabetes group.Pearson correlation analysis was performed between HbA1c and Lp-PLA2.The results showed that there was a significant positive correlation between HbA1c and Lp-PLA2 in patients with type 2 diabetes mellitus(r=0.33,P<0.05).Conclusion Lp-PLA2 is involved in the occurrence and development of type 2 diabetes mellitus and its complications.Regular monitoring of related indicators is of great clinical significance for prevention,treatment and reduction of complications in diabetic patients.