Objective To evaluate the clinical effects of bladder perfusion combined with deep hyperthermia on preventing postoperative recurrence of non-muscle invasive bladder cancer.Methods Choose 98 patients with NMIBC who were treated with transurethral bladder cancer resection,and randomly divide them into two groups,research group and control group,49 cases in each.Giving MMC bladder perfusion chemotherapy to the control group,and added deep hyperthermia to the research group on the basis of bladder peffusion.Contrast the relapse rates and condition of adverse events during treatment.Resnits The relapse rates of research group when treatment was continued for 6,9,12,15,18 months were significantly lower than that of control group(4.08％ VS 10.20％,6.12％ VS 12.24％,10.20％ VS 18.37％,10.20％ VS 20.41％,14.29％ VS 24.50％,all P ＜ 0.05).No statistical significance in adverse events between each group was observed (P ＞ 0.05).Conclusion MMC bladder perfusion combined with deep hyperthermia therapy has great clinical value,as it can reduce the rates of postoperative recurrence of NMIBC,as well as not increase the AEs of bladder perfusion.