Chinese Journal of Medical Imaging Technology 2017;33(10):1550-1553

doi:10.13929/j.1003-3289.201703090

Current status of quantitative multimodality MRI features and IDH gene mutation in gliomas

Dongdong MEI 1 ; Jingshan GONG ; Yongguang LIU ; Xia FENG

Affiliations

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Keywords

Isocitrate dehydrogenase; Mutation; Gliomas; Magnetic resonance imaging

Country

China

Language

Chinese

Abstract

The mutation of isocitrate dehydrogenase (IDH) gene is associated with gliomagenesis.It has also significant positive effects on survival and chemosensitivity in comparison with IDH wild-type glioma.Being an important energetic metabolism enzyme,mutation of IDH results in changes of microstructures and metabolism.Quantitative multimodality MR imaging has ability to obtain imaging biomarkers about microstructural,physiologic and functional information,which demonstrates the promises to assess IDH gene status in vivo.The progresses of association between quantitative multimodality MRI features and IDH genesmutations in glioma were reviewed in this paper.