Chinese Critical Care Medicine 2017;29(10):954-957

doi:10.3760/cma.j.issn.2095-4352.2017.10.020

Progresses of immunomodulatory therapy in sever acute pancreatitis

Guangming HE 1 ; Guanze XIONG ; Song LU ; Shanling XU ; Keling CHEN

Affiliations

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Keywords

Sever acute pancreatitis; Imbalance of immune response; Immunomodulatory therapy; Inflammatory response

Country

China

Language

Chinese

Abstract

Severe acute pancreatitis (SAP) is accompanied with complex pathogenic course and high mortality. The imbalance of immune response is an important cause which leads the SAP patients to the severe situation and even death. The immunomodulatory therapy can regulate the imbalance of inflammation, alleviate SAP-associated organ injury, and improve the prognosis of patients. Previous immunomodulatory therapy had some problems, such as single-object and simple-method. In recent years, some new methods of immunomodulatory therapy, such as regulating the apoptosis and mature of immune cells, applying of mesenchymal stem cells (MSCs) and multi-regulation methods, provide some new ideas and hopes for SAP therapy. This paper reviewed the history and recent research progresses of SAP immunomodulatory therapy.