Objective To investigate the clinical effect of adjustable negative pressure drainage technique in the treatment of subcutaneous acute cellulitis.Methods Thirty patients with acute cellulitis were treated with adjustable pressure drainage technique after incision and drainage of subcutaneous infection.Results 22 patients with subcutaneous infectious wounds took the secondary suture after carrying out one-time regulated negative pressure therapy,and 8 patients with subcutaneous infectious wounds took the secondary suture after carrying out twice negative pressure therapies.The average time of negative pressure treatment was (7.3 ± 1.0) days.Thirty patients had subcutaneous infection wounds healed well and no recurrence was observed at 3 months follow-up.ConclusionThe repairment of negative pressure therapy adopted to treat the subcutaneous acute cellulitis can rapidly reduce the local and general symptoms of the patient,and apparently reduce the dressing change times.With simple operation and reliable curative effect the relapse rate of subcutaneous infectious wound can be enormously reduced.