Breast paget's disease is a rare form of breast cancer,proposed by James Paget's in 1874.The pathogenesis of Paget's disease has been controversial;there are two main theories are epiphytic theory and trans-formation theory.In recent years,with the pathogenesis of breast Paget's disease development,some new hypothe-ses are input such as factor and receptor theory,endocrine theory and virus theory.Breast Paget's treatment meth-ods include improved radical surgery,simple breast resection,breast conserving surgery and other surgical treat-ment,according postoperative pathology combined with radiotherapy and chemotherapy.For those who have strong breast protection or plastic surgery will be given to patients with photodynamic therapy for neoadjuvant therapy. This paper reviews the relevant theories and hypotheses about the pathogenesis of mammary gland by collecting re-lated literatures in recent years.