The current detection of serum tumor markers is still considered to be one of convenient and effective means for early diagnosis of tumor and monitoring tumor progression.Golgi phosphoprotein 2(GOLPH2) is a type Ⅱ transmembrane protein presenting in the Golgi apparatus.In recent years,many studies have suggested that GOLPH2 is one of the most promising early serum markers for early diagnosis of tumor.In addition,many studies have beer shown that GOLPH2 is related to prognosis of lung cancer,gastric cancer,prostate cancer and other cancer-related prognosis involved in immune regulation,intracellular signal factor activation and degrada-tion and promote epithelial-mesenchymal transition(EMT).Through these mechanisms to promote tumor pro-gression and metastasis,GOLPH2 reduces the disease-free survival(DFS)and overall survival(OS).In this pa-per,we review the role of GOLPH2 in the progress and a variety of malignant tumors.