Breast cancer is one of the highest incidence of cancer in women,most frequent sites of metas-tasis are the lung,bone,liver,and central nervous system.The incidence of central nervous system metastasis is a-bout 15%.At present,there are Wnt and Notch pathways,EGFR and PTEN pathways,which may be related to the brain metastases in breast cancer.There may be related to VEGF and Stat 3,tubulin and TOP2A,BNC1,GALNT9, CCDC8,HER2,HER3,MMP,FBPS,sarcosine and other factors.This paper summarizes the signaling pathways and molecular mechanisms that may lead to brain metastases in breast cancer,and we hope to provide new ideas for targeted therapy of brain metastases in breast cancer.