PURPOSE: The purpose of this study was to determine the effects of empowerment education program on self-efficacy, self-care agency, self-care activities and physiologic parameters among hemodialysis patients. METHOD: Nonequivalent control group pretest-posttest design was used. There were 36 subjects in the experimental group and 35 subjects in the control group. The empowerment education program was administered for 4 weeks (1 time per week). Data were collected pre-treatment and post treatment. The chi2-test or Fisher's exact test, ANCOVA, t-test and paired t-test were performed to determine the group differences, using SPSS 14.0 version. RESULTS: Self-efficacy, self-care agency, self-care activities and weight variation significantly improved after the empowerment education program in hemodialysis patients. CONCLUSION: The empowerment education program for hemodialysis patients was effective to improve the degree of self-efficacy, self-care activities and self-care agency and to decrease interdialytic weight variation.