Journal of Bacteriology and Virology 2015;45(1):62-66
doi:10.4167/jbv.2015.45.1.62
Heat Shock Protein 90 (HSP90) and Immune Regulation.
Bo Kyung KIM 1 ; So Youn WOO
Affiliations
Keywords
Heat shock protein 90 (HSP90); Anti-inflammatory; HSP90 inhibitor; IL-17; Act1
Country
Republic of Korea
Language
Korean
MeSH
ACTIONS
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Abstract
Heat shock protein 90 (HSP90) is involved in conformational and structural maturation of signalling molecules and transcription factors in immune reaction. HSP90 inhibitors induce immune modulation via anti-inflammatory effect, regulating humoral and cellular immune responses. Therefore, HSP90 inhibitors potentially useful target for the autoimmune disease and chronic inflammatory diseases.
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