The Korean Journal of Critical Care Medicine  2012;27(1):1-4

doi:10.4266/kjccm.2012.27.1.1

Transfusion-related Acute Lung Injury.

Miok KIM 1

Affiliations

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Keywords

acute lung injury; blood transfusion

Country

Republic of Korea

Language

Korean

Abstract

Transfusion-related acute lung injury (TRALI) is a significant cause of iatrogenic injuries in patients. It is also the major cause of transfusion-associated fatalities. Pathophysiologic mechanism is an implicated donor of HLA. Neutrophil antibodies and biologic response modifiers are accumulated in the stored blood products. Pulmonary endothelial activation of the host may be the response from these mediators. Treatment is supportive and will be subjected to other forms of ALL/ARDS. Diverting donors at high risk for alloimmunization may decrease the incidence of such cases.