Korean Journal of Anatomy  2007;40(4):347-357

Locations of Slow-Cycling Cells, Adult Stem Cells, in the Organs of Adult Mouse.

Jinu KIM 1 ; Kwon Moo PARK

Affiliations

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Keywords

BrdU-retaining cell; Slow-cycling cell; Adult stem cell; Plasticity

Country

Republic of Korea

Language

Korean

Abstract

Adult stem cells possess the characteristics of self-renewal, multipotent, plasticity as well as slow cycling rate. We investigated a location of slow-cycling cells, that is, adult stem-like cells, in various organs in the 8 week-old mice which administered bromodeoxyuridine (BrdU) at neonatal phase. BrdU-retaining cells (slow-cycling cells) were observed in speramtogonia at the edge of seminiferous tubules in testes, hair root cells surrounding hair follicles, the cells in the inner nuclear layer of the retina, the myocytes in the hearts, the cells in the parenchyma and the Glisson's capsule of liver, the cells in the epithelial layer of bronchioles, and the tubular epithelial cells in the kidneys. In conclusion, various organs of adult mouse expressed slow-cycling cells, indicating that the cells may associate with normal cell turnover and repair after damages.