Journal of Korean Neuropsychiatric Association  2002;41(5):942-946

Atypical Antipsychotic Drug Induced Diabetes Mellitus.

Myoung Sun ROH 1 ; Young Jin KOO ; Yong Min AHN ; Ung Gu KANG ; Yong Sik KIM

Affiliations

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Keywords

Atypical antipsychotics; Clozapine; Olanzapine; Diabetes mellitus; Hyperglycemia

Country

Republic of Korea

Language

Korean

Abstract

BACKGROUND: Atypical antipsychotics have been reported to affect glucose-insulin homeostasis and possibly induce diabetes mellitus. Here, we present five cases in which clozapine or olanzapine treatment were associated with de novo onset of diabetes mellitus. CASE REPORTS: Three out of the five cases had risk factors for diabetes and developed diabetes during the early phase of treatment with atypical antipsychotics. However, it took longer for the other two patients with no risk factor for diabetes to manifest symptoms of diabetes. In all of the cases, we were able to control their plasma glucose level within clinically tolerable range by applying diverse treatment modalities for diabetes mellitus and continue with antipsychotics treatment. CONCLUSION: These findings suggest that risk factors for diabetes such as family history of diabetes and baseline obesity may be related to development and time of onset of atypical antipsychotic drugs induced diabetes.