Journal of Korean Geriatric Psychiatry  2015;19(2):97-100

Reduced Cortical Thickness in Patients with Late Life Depression without Cerebral Vascular Disease.

Kang Yoon LEE 1 ; Young Min LEE ; Je Min PARK ; Byung Dae LEE ; Eun Soo MOON ; Hee Jeong JEONG ; Young In CHUNG ; Ji Hoon KIM

Affiliations

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Keywords

Late life major depression; Cortical thickness; Magnetic resonance imaging

Country

Republic of Korea

Language

Korean

Abstract

OBJECTIVES: The aim of this study is to compare cortical thickness in late life major depression patients without cerebral vascular disease (CVD) with that of non-depressed normal comparison subjects using magnetic resonance imaging (MRI). METHODS: Altogether, 47 subjects were finally recruited from the Memory impairment clinics of Pusan National University Hospital in Korea. All subjects (late life major depression patients without CVD : n=21, matched non-depressed normal comparison subjects : n=26) underwent 3-tesla MRI. RESULTS: Late life major depression patients without CVD showed reduced cortical thickness in left precuneus, left inferior temporal gyrus, and left cuneus compared with non-depressed normal comparison subjects. CONCLUSION: Our findings suggest that late life major depression without CVD is associated with reduced cortical thickness.