Journal of Forensic Medicine 2017;33(3):284-288

doi:10.3969/j.issn.1004-5619.2017.03.015

Research Progress of the Correlation between Caveolin and Unexpected Sudden Cardiac Death

Fangyu WU ; Lianlei GAI ; Xiaoping KONG ; Bo HAO ; Erwen HUANG ; He SHI ; Lihui SHENG ; Li QUAN ; Shuiping LIU ; Bin LUO

Keywords

forensic pathology; death,sudden,cardiac; review; caveolin; ion channel; arrhythm ias,cardiac

Country

China

Language

Chinese

Abstract

D ue to the negative autopsy and w ithout cardiac structural abnorm alities, unexpected sudden cardiac death (U SC D ) is alw ays a tough issue for forensic pathological expertise. U SC D m ay be asso-ciated w ith parts of fatal arrhythm ic diseases. T hese arrhythm ic diseases m ay be caused by disorders of cardiac ion channels or channel-related proteins. C aveolin can com bine w ith m ultiple m yocardial ion channel proteins through its scaffolding regions and plays an im portant role in m aintaining the depolar-ization and repolarization of cardiac action potential. W hen the structure and function of caveolin are af-fected by gene m utations or abnorm al protein expression, the functions of the regulated ion channels are correspondingly im paired, w hich leads to the occurrence of m ultiple channelopathies, arrhythm ia or even sudden cardiac death. It is im portant to study the effects of caveolin on the functions of ion channels for exploring the m echanism s of m alignant arrhythm ia and sudden cardiac death.