Journal of Forensic Medicine 2017;33(3):289-292

doi:10.3969/j.issn.1004-5619.2017.03.016

Research Progress of the Relationship between the Expression of TAR DNA-bind-ing Domain Protein 43 and Brain Injury

Yao YE ; Rubo LI ; Shiyu MA ; Xueting WEI ; Qi XU

Keywords

forensic pathology; brain injuries; review; T A R D N A-binding dom ain protein 43

Country

China

Language

Chinese

Abstract

T A R D N A-binding dom ain protein 43 (T D P-43) is a highly conserved and w idely expressed nuclear protein. N ow adays, the expression of T D P-43 can be found in m ost neurodegenerative diseases such as A lzheim er's disease, w hich m akes it becom e a neurodegenerative disease associated m arker pro-tein. From the current research status at hom eland and abroad, and around the relationship betw een the expression of T D P-43 and brain injury, this article em phatically probes into the specific expression and function of T D P-43 in acute and chronic brain injury based on the know ledge of its biological charac-teristics, w hich aim s to explore the feasibility for determ ining the cause of death and the injury and dis-ability situations by T D P-43 in forensic pathology.