Journal of China Pharmaceutical University 2017;48(2):157-166

doi:10.11665/j.issn.1000-5048.20170205

Synthesis and antiproliferative activities of 5H-benzo[b] carbazole-6,11-diones

Sufen CAO ; Qin XIE ; Yi CHEN ; Wenhu DUAN

Keywords

5H-benzo[b] carbazole-6,11-dione; synthesis; antiproliferative activity

Country

China

Language

Chinese

Abstract

A series of 5H-benzo[b] carbazole derivatives were synthesized to find new TopⅡ inhibitors.The substitution pattern at C-9 was discussed.All 16 compounds were tested for their antiproliferative activities against 4 tumor cell lines (SMMC-7721,S1,HCT116,and HeLa) by sulforhodamine B assay.Four compounds were found to inhibit the proliferation of all tested cell lines.And compound 10e displayed the best antiproliferative activity against all 4 tested cell lines with IC50 values of 5.06,4.50,5.29,and 6.32 μmol/L,respectively.