Parasitosis is one of the most serious infectious diseases endangering human and animal health. Vaccination was an economic and effective measure in prevention and treatment of the disease. Bifidobacterium (Bb) is a kind of important probiotics in intestinal tract of human and other animals. In recent years, with the development of genetic engineering technology, Bb has been selected as a carrier delivery system to construct a series of recombinant Bb, such as in bacteria, viruses, parasites, tumor and other fields. In this review, we reported the preparation and immune effect of several kinds of Bb-mediated genetic engineering vaccines against parasites.