Chinese Journal of Health Management 2017;11(4):383-387

doi:10.3760/cma.j.issn.1674-0815.2017.04.018

Biomarkers in early diagnosis and screening of lung cancer

Shijia ZHANG ; Jing ZHAO ; Shengxiang REN ; Caicun ZHOU

Keywords

Biological markers; Early diagnosis; Lung neoplasms; Screening

Country

China

Language

Chinese

Abstract

Early diagnosis and screening are of great significance for improving the prognosis of patients with lung cancer. Low-dose helical computed tomography (LDCT) reduces lung cancer mortality by about 20％, making it the most effective screening tool. However, high false-positive rates, costs, and potential harms highlight the need for complementary biomarkers. The diagnostic performance of biomarkers such as noninvasive autoantibody and plasma/serum microRNA (miRNA) were shown in several studies, making them approved for early diagnosis in our country, Europe and the United States, and their role in screening is being explored in ongoing studies.