Practical Oncology Journal 2017;31(4):376-380

doi:10.11904/j.issn.1002-3070.2017.04.017

Research progress of MSI colorectal cancer

Yue MA

Keywords

MSI; Mucinous adenocarcinoma; PD-1; CIMP; BRAF

Country

China

Language

Chinese

Abstract

Colorectal cancer is one of the most common malignant tumors,with the improvement of living standards and eating habits of Westernization.The incidence and mortality of colorectal cancer are on the rise in China.The development of colorectal cancer is a multi-step,multi-gene involved in the process.At present,chromosome instability(CIN)and microsatellite instability(MSI)are considered to be the main genetic pathways in colorectal cancer.This article reviews research progress of MSI colorectal cancer in clinical pathology and molecular characteristics.