Journal of Shanghai Jiaotong University(Medical Science) 2017;37(8):1169-1173

doi:10.3969/j.issn.1674-8115.2017.08.024

Activation mechanism and therapeutic use of microglia in subarachnoid hemorrhage

Shuo HAN ; Tao Lü ; Xiaohua ZHANG

Keywords

microglia; subarachnoid hemorrhage; vasospasm; activation mechanism

Country

China

Language

Chinese

Abstract

Microglia are activated and involve in the pathological and physiological processes of early brain injury and delayed cerebral ischemia after subarachnoid hemorrhage, thus impact the outcome of patients. Numerous studies have shown that microglia have different typings, signaling pathways,and functions. Interference with microglial activation or reduction of cytotoxic metabolites is important for improving the prognosis of SAH patients.