To investigate the expression of CMaf inducing protein(CMIP) in human laryngeal squamous cell carcinoma and polyps tissues,and to analyze their association with clinicopathological parameters and survival of patients with laryngeal squamous cell carcinoma.Methods Real-time PCR assay was used to detect the expression of CMIP mRNA in 28 cases of laryngeal squamous cell carcinoma and 23 cases of polyp fresh tissue specimen.Immunohistochemical staining was used to detect the expression of CMIP in 86 cases of formalin-fixed and parrffin-embedded laryngeal squamous cell carcinoma and 29 cases of polyp tissue specimens.The clinicopathological and prognostic significance of CMIP expression was investigated in laryngeal squamous cell carcinoma.Results The expression of CMIP mRNA and protein was both significantly increased in laryngeal squamous cell carcinoma compared with polyp tissue specimens.The expression of CMIP was significantly associated with tumor lymph node metastasis and late clinical stage of laryngeal squamous cell carcinoma.Furthermore,the expression of CMIP was significantly correlated with poor relapse-free survival and overall survival in laryngeal squamous cell carcinoma.Conclusion CMIP might play an important role in the development and progression of laryngeal squamous cell carcinoma and increased expression of CMIP might imply disease progression and poor outcome in patient with laryngeal squamous cell carcinoma.