Recent Advances in Ophthalmology 2017;37(5):480-483

doi:10.13389/j.cnki.rao.2017.0122

Recent advances in immune regulation of mesenchymal stem cells on autoimmune dry eve

Xilian WANG ; Xiaoxiao LU ; Liyuan YANG ; Hong NIAN ; Ruihua WEI

Keywords

mesonchymal stem cells; autoimmune dry eye; immunoregulation

Country

China

Language

Chinese

Abstract

Mesenchymal stem cells (MSCs) have good immune regulatory function,can inhibit many immune cell proliferation,direct effects on activation and proliferation of T cell,play a role in immune regulation by Treg cells or by the secretion of soluble factors regulating Thl/Th2 secretion and reaction equilibrium,inhibit the inflammation through the anti-inflammatory,regulation of cytokines expression at the same time,so reduce the expression levels of matrix metalloproteinase-2 and-9,which may promote lacrimal gland tissue damage,and thus play a role in immune regulation.MSCs can reduce the autoimmune dry eye clinical index,recovery secretion function of part lacrimal gland.This article reviews the research advances in inmmmne regulation of MSCs on autoimmune dry eye.