Journal of Forensic Medicine 2017;33(2):181-188

doi:10.3969/j.issn.1004-5619.2017.02.016

Confirming Indicators of Qualitative Results by Chromatography-mass Spectrome-try in Biological Samples

Shaodan LIU ; Daming ZHANG ; Wei ZHANG ; Wenfang ZHANG

Keywords

forensic toxicology; chrom atography; m ass spectrom etry; review; quality control; qualitative research; confirm ing indicator; biological sam ple

Country

China

Language

Chinese

Abstract

B ecause of the exist of com plex m atrix, the confirm ing indicators of qualitative results for toxic substances in biological sam ples by chrom atography-m ass spectrom etry are different from that in non-biological sam ples. E ven in biological sam ples, the confirm ing indicators are different in various ap-plication areas. T his paper review s the sim ilarities and differences of confirm ing indicators for the ana-lyte in biological sam ples by chrom atography-m ass spectrom etry in the field of forensic toxicological analysis and other application areas. T hese confirm ing indicators include retention tim e (R T ), relative re-tention tim e (R R T ), signal to noise (S/N ), characteristic ions, relative abundance of characteristic ions, parent ion-daughter ion pair and abundance ratio of ion pair, etc.