Objective To observe the clinical curative effect of skin-region drainage therapy combined with Sanpian Decoction in treating migraine.Methods A total of 90 cases of migraine patients were randomly divided into combination group and acupuncture group,45 cases in each group.The combination group was treated with skinregion drainage therapy combined with oral use of Sanpian Decoction,and the acupuncture group was treated with conventional acupuncture therapy.Seven days constituted one treatment course,and the clinical efficacy of the two groups was evaluated after 3 courses of treatment.Results (1) The total effective rate of the combination group and acupuncture group was 95.6％ and 82.2％ respectively,and there were significant differences between the two groups (P ＜ 0.05).(2) After treatment and 3 months after treatment suspension,the pain scores of the two groups were significantly decreased(P ＜ 0.01 compared with those before treatment),and the pain scores of the combination group were lower than those of the acupuncture group (P ＜ 0.01).Conclusion The skin-region drainage therapy combined with Sanpian Decoction exerts certain effect in treating migraine.