Progress in Modern Biomedicine 2017;17(22):4391-4393,4267

doi:10.13241/j.cnki.pmb.2017.22.046

Research Progress of SERPINE Family in Fibrosis Disease

Tianshi LI ; Zhenfeng GUO ; Muge QILI ; Dandan ZHAO ; Xuelian LI

Keywords

SERPINE; Plasminogen activator inhibitor (PAI-1); Serine protease inhibitors (PN-1); Fibrosis

Country

China

Language

Chinese

Abstract

Serine protease inhibitor (serpin) is a kind of serine protease activity regulator,which including nine subfamilies (SERPIN A ～ I).SERPINE (Serpin Peptidase Inhibitor,Clade E) can regulate many important life processes.In this paper,the physical and chemical properties,mechanisms and regulatory factors of SERPINE1 and SERPINE2 in the two important members of SERPINE family are introduced,and the research progress of SERPINE family in the fibrosis related diseases is described.