Chinese Journal of Forensic Medicine 2016;31(6):587-590,594

doi:10.13618/j.issn.1001-5728.2016.06.014

Cell-free fetal nucleic acid in maternal plasma and noninvasive prenatal paternity testing

Jin YU ; Chao XIAO ; Daixin HUANG

Keywords

forensic biological evidence; noninvasive prenatal paternity testing; cell-free fetal nucleic acid; differentially methylated region

Country

China

Language

Chinese

Abstract

In recent years, the cases of prenatal paternity testing gradually increased in forensic practice. The traditional prenatal paternity analysis can be performed only after invasive sampling of chorionic villi or amniotic fluid, which can result in a risk of miscarriage. The existence of circulating cell-free fetal nucleic acid in maternal plasma has brought new opportunities for the noninvasive prenatal paternity testing. In this paper, the research situation and application prospect of circulating cell-free fetal nucleic acid in maternal plasma in prenatal paternity testing are reviewed.