Chinese Herbal Medicines 2011;03(1):64-65,74

doi:10.3969/j.issn.1674-6384.2011.01.013

A New Alkaloid from Bombycis Feculae and Its a-Glucosidase Inhibitory Activity

Yuanyuan ZHU ; Zhihong WANG ; Hui QI ; Gang BAI

Keywords

alkaloid; Bombycis Feculae; 1-deoxynojirimycin; 1,3-dideoxygalatonojirimycin; a-glucosidase inhibitor

Country

China

Language

Chinese

Abstract

Objective To study the chemical constituents of Bombycis Feculae. Methods Chemical constituents were isolated BPLC-ELSD. The structures of the isolated compounds were determined by spectral means. Results Two compounds were isolated and identified as 1-deoxynojirimycin (1) and (2R,3R,5R)-2-(hydroxymethyl)piperidine-3,5-diol, named as 1,3-dideoxygalatonojirimycin (2). Conclusion Compound 2 is a new alkaloid. The extract of Bombycis Feculae, compound 1 and compound 2 show inhibitory activities against a-glucosidase.