Journal of Laboratory Medicine and Quality Assurance  2004;26(1):147-170

Annual Report on External Quality Assessment in Diagnostic Genetics in Korea (2003).

Hyoun Chan CHO 1 ; Sun Hee KIM ; Sung Sup PARK ; Sang Gon LEE ; Sung Hee HAN ; Eun Kyoung NA ; Jae Seok KIM ; Jeong Eun LEE ; Eui Chong KIM ; Suk Ja PARK ; Jong Woo PARK ; Soon Pal SEO ; Kyung Soon SONG ; Yu Kyung LEE ; Hyun Sook CHI

Affiliations

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Keywords

External quality assurance; Diagnostic genetics; Cytogenetics; Molecular genetics

Country

Republic of Korea

Language

Korean

Abstract

The importance of quality control for dramatically growing genetic tests continues to be emphasized with increasing clinical demands. Diagnostic genetics subcommitee of KSQACP performed two trials for cytogenetic study in 2003. Cytogenetic surveys were performed by 33 laboratories and answered correctly in most laboratories except some problems in nomenclature and analysis for FISH and complex cytogenetic abnormalities in neoplasia. The molecular genetic test surveys include M. tuberculosis, HBV, HPV, leukemia/lymphoma, ApoE genotyping, Duchenne muscular dystrophy, myoclonic epilepsy and ragged red muscle fibers, and spinal and bulbar muscular atrophy. HPV, myoclonic epilepsy and ragged red muscle fibers, and spinal and bulbar muscular atrophy were the first challenge of the genetic survey. Molecular genetic survey showed excellent results in most participants, however, HPV tests should be improved by quality control in a few laboratories. External quality assessment program for cytogenetic analysis could be helpful to give participants many chances of continuous education and of interesting case materials.