Chinese Journal of Zoonoses 2014;(10):1066-1070,1078

doi:10.3969/cjz.j.issn.1002-2694.2014.10.017

Recombinant protein of Echinococcus g ranulosus EG95

Hongmin LI ; Zhongzi LOU ; Li LI ; Zhenhua LI ; Jianqiu LI ; Hongbin YAN ; Wanzhong JIA

Keywords

Echinococcus granulosus; EG95 gene; recombinant antigen; vaccine; expression system; immuno-protec-tive effect

Country

China

Language

Chinese

Abstract

Echinococcosis (hydatid disease) caused by the metacestodes of Echinococcus granulosus tapeworm is a seri-ous zoonotic infection ,which leads to a large amount of economic loss in human and animals .It needs to be prevented urgently . The EG95 protein is highly conserved and crucial for survival and development of E .granulosus in the host ,which means that it is one of the potential candidate antigens for vaccines characterized so far .Great effort has been made to construct and ex-press the recombinant EG95 (rEG95) gene in various kinds of expression systems in order to obtain an efficient defined antigen . This review will summarize research progress on expression of rEG95 in different vector systems .