Biomolecules & Therapeutics  2013;21(4):284-289

Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins.

Su Hee HONG 1 ; Jee In HEO ; Jeong Hyeon KIM ; Sang Oh KWON ; Kyung Mok YEO ; Anna M BAKOWSKA-BARCZAK ; Paul KOLODZIEJCZYK ; Ok Hyun RYU ; Moon Ki CHOI ; Young Hee KANG ; Soon Sung LIM ; Hong Won SUH ; Sung Oh HUH ; Jae Yong LEE

Affiliations

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Keywords

Antidiabetes; Purple corn anthocyanins; Beta cell-protection; Antihyperglycemic activity; Pancreatic beta cell; db/db Mice

Country

Republic of Korea

Language

English

Abstract

Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells. PCA had excellent antihyperglycemic activity (in terms of blood glucose level and OGTT) and HbA1c-decreasing activity when compared with glimepiride, a sulfonylurea in db/db mice. In addition, PCA showed efficient protection activity of pancreatic beta cell from cell death in HIT-T15 cell culture and db/db mice. The result showed that PCA had antidiabetic and beta cell-protection activities in pancreatic beta cell culture and db/db mice.